Leading animal health company Elanco has announced Zolvix Plus – a leading broad spectrum drench used in the sheep industry – is now registered for use in beef and non-lactating dairy cattle.
Zolvix Plus is an innovative combination drench which contains 25 g/L monepantel and 2 g/L abamectin.
Monepantel belongs to the amino-acetonitrile derivative – or ‘orange’ – family of anthelmintics, the first new broad spectrum drench class to be registered for use in cattle in Australia for nearly 40 years.
Elanco brand manager, Dave Rathbone, says the registration is exciting news for beef and dairy producers.
“Zolvix Plus contains Monepantel, representing the only member of the first new broad spectrum drench class for cattle to be introduced to Australia since the ‘mectins’ were introduced in the mid-80s,” he says. 1
“Producers have access to dozens of broad-spectrum drenches, but they all belong to three chemical groups.
“Resistance to all three of these groups has been reported in all major worm species in Australia. 2-4
“Put simply, it’s time for beef and dairy producers to incorporate new and fully effective chemistry into their drenching program.”
Zolvix Plus is registered for the control of all of the most important worm species found in young cattle 5, including Haemonchus, Ostertagia, Cooperia and Oesophagostomum (adult only).
Dose determination and dose confirmation studies have shown Zolvix Plus provides >98 per cent efficacy against all major worm species, while Australian field trials demonstrated 99.9 per cent efficacy. 6,7
“This proven efficacy means Zolvix Plus will be particularly suitable for use in worm control programs in young cattle, which are more susceptible to parasite burdens,” Dave says.
“Zolvix Plus is also ideal for use in ‘quarantine’ drenching programs.
“Best practice guidelines recommend treating all introduced cattle using a drench that contains as many unrelated active ingredients as possible to prevent any worms, particularly resistant strains, from being introduced to the property.” 8
Zolvix Plus will also have a role to play in maintaining the efficacy of older active ingredients.
“Monepantel and abamectin are both broad spectrum drenches with different modes of action, so they are ideal combination partners,” Dave says.
“The use of drenches containing two or more active ingredients can maximise efficacy and help to prolong the life of all available chemistry.” 9
Zolvix Plus is administered orally at a dose of 1 mL/10 kg body weight using the Zolvix Plus 30 mL Cattle Oral Drencher.
It can be administered to beef and dairy calves more than 100kg liveweight or at least 16 weeks of age.
Zolvix Plus has a meat withholding period of 12 days and an export slaughter interval of 61 days when used in beef and dairy cattle.
Do not use in lactating cows or within 49 days of calving where milk may be used or processed for human consumption.
The minimum re-treatment interval is 21 days.
After three consecutive treatments, 61 days must elapse before treating again.
References: 1. Gilleard, J., et al. (2021). A journey through 50 years of research relevant to the control of gastrointestinal nematodes in ruminant livestock and thoughts on future directions. Int J Parasitol 51:1133–1151. 2. Allworth, B. et al. (2023). Comparison of the efficacy of macrocyclic lactone anthelmintics, either singly or in combination with other anthelmintic(s), in nine beef herds in southern NSW. Aust Vet J 101(8):293-295. 3. Bullen, S. et al. (2016). Anthelmintic resistance in gastrointestinal nematodes of dairy cattle in the Macalister Irrigation District of Victoria. Aust Vet J 94(1-2):35-41. 4. Wonders, N (2016). What does anthelmintic resistance mean for worm treatment in cattle? Proceedings of the Australian Cattle Veterinarians Conference, Ayers Rock, Northern Territory, 129-130. 5. https://wormboss.com.au/roundworms/ 6. Elanco data on file (YAR-13-028, YAR-13-042, NAH-14-207, NAH-15-369 & YAR-13-041). 7. Elanco data on file (NAH-13-039, NAH-13-040, NAH-13-041 & NAH-13-042). 8. https://wormboss.com.au/quarantine-drenching/
9. https://wormboss.com.au/using-the-appropriate-drench/combination-drenches/
